We assume leadership of Gastroenterology with a blend of humility, trepidation, and excitement. There have been many eminent Editors-in-Chief of Gastroenterology, including our immediate predecessors, Richard M. Peek, Jr, MD, AGAF, and Douglas A. Corley, MD, PhD, who led the journal to its highest impact factor on record. We are humbled to take the reins from such an illustrious pair and hope we can match their innovation, enthusiasm, and rigor. Gastroenterology will continue to raise the bar as the leading journal in our specialty. We are trepidatious, as this preeminent position is under threat. Gut and other established journals are upping their game, and newer journals, such as Lancet Gastroenterology and Hepatology, come from a highly successful family of journals. We view this competition as healthy and are optimistic that our new, outstanding editorial team will maintain and enhance Gastroenterology’s enviable reputation. We are excited to continue the evolution of a journal with nearly 80 years of continuous publication. The American Gastroenterological Association (AGA) was founded in 1897 by a group of young, dynamic, academic physicians interested in gastrointestinal (GI) diseases. It is the oldest GI society in the world. Since its inception, the proceedings of the AGA annual meeting were published, but it was not until 1943 that Gastroenterology was conceived to meet members’ needs. Initially, content was exclusively from US-based researchers who were invited to submit case reports and clinical observations. Gradually, this changed to a competitive model of submission with a concurrent shift toward basic science content. More recently, AGA itself has evolved from an organization primarily for GI researchers to one with a broader membership dominated increasingly by clinical gastroenterologists. The clinical research published in the journal benefitted from improved research methodology with the development of epidemiology and a focus on evidence-based medicine. Today, Gastroenterology’s original content is divided roughly equally between basic and clinical research. As AGA has expanded its non-US membership, Gastroenterology also published more research from international researchers. As we will describe, we have sought to expand our global editorial presence. We hope this will continue to improve our ability to identify and to publish the very best GI research from around the world. We still aim to publish both clinical and basic research in roughly equal measure, but we will be particularly interested in basic science, where the translation to the understanding or management of disease is apparent. Emphasizing the connection between the bench and the bedside is essential to ultimately improve clinical outcomes. Not every innovative laboratory discovery will translate into patient care but, if it is interesting, we would like to publish the work in Gastroenterology. Similarly, we would like to publish the best clinical research that clearly demonstrates an ability to inform patient care. Finally, we want to publish articles that excite our readers, from innovative educational materials to thought-provoking commentaries. This brief introduction is not meant to be encyclopedic. We are deeply honored to assume the editorial direction of Gastroenterology. We are not afraid to try new things, with full knowledge that some will not work as well as we had hoped. Along with our other Board members, we claim no monopoly on good ideas. We will always welcome suggestions from our readers about how we can do our jobs better. Historically, Gastroenterology had one Editor-in-Chief with the majority of the Board of Editors drawn from a single institution. The adoption of the Co-Editors-in-Chief model provided an opportunity to expand the base from which editorial team members could be selected. Geographic distance required the development of virtual editorial meetings long before COVID-19 made all of us experts in using virtual platforms. The good news is that editorial meetings flourished despite the challenges of multiple time zones. Building on our predecessors’ experience, we have taken the opportunity to invite a truly international group of experts to form the incoming Board. We consider ourselves remarkably fortunate to have attracted such a stellar group of colleagues from 10 countries and 4 continents. All have extensive editorial experience; 8 have served as Editors-in-Chief of other journals. The great majority have MDs or equivalent, which should help with our focus on the translational components of basic research. When compiling our editorial application, we were amazed, and perhaps even a little intimidated, to note that our team had nearly 12,500 peer-reviewed publications that have been cited more than 650,000 times, according to Web of Science. The stature of the new Board of Editors is exemplified by 6 of the team being on the Clarivate Highly Cited Researchers 2021 list of the top 0.1% of world researchers in any field from the last decade. Our colleagues understand first-hand the challenges associated with high-quality research, as well as the essential role played by rigorous, constructive peer review. Although the journal is a proud member of the AGA family, the research and patient care needs of readers from around the world will be addressed regularly in the original research, commentaries, and guidelines we look to publish. Paul Moayyedi, MD, PhD, AGAF, is Gastroenterology’s first non-US citizen Editor-in-Chief. In addition to casting a broad net for submissions addressing orthodox GI issues, we plan to periodically feature broader topics not specific to GI, but that we hope are of interest to our readers, such as “how do mRNA vaccines work?” or “what is CRISPR?” The AGA is dedicated to improving inclusion in our specialty. Gastroenterology was the first major GI journal to appoint an editor specifically to address diversity. We will continue that initiative with Sandra Quezada, MD, AGAF, as our diversity lead, who will work to mitigate bias and ensure that all content addresses sex, race, and other dimensions of diversity appropriately. In addition, original research and commentaries will regularly address issues related to sex, gender, sexual orientation, and race related to research, training, and clinical practice. We also realize that, increasingly, our readers can also be our patients or participants in our research projects. We will be the first major GI journal to include patient partners and, on occasion, we will present the patients’ voice to remind clinicians and researchers that what patients consider important may not coincide with our own perceptions. Gastroenterology has always endeavored to meet the changing needs of readers and to adapt in the evolving world of medical publishing. More readers want digital as well as print versions. Social media is a vital avenue to promote content. Today, most readers of our journal are clinicians, but we believe all readers, regardless of background, understand the key role of journals like Gastroenterology to identify and disseminate clinical, translational, and basic research. Historically, Gastroenterology has presented material in somewhat artificial silos, such as basic science articles involving the alimentary tract or clinical articles involving the liver. The distinction between a basic research article and a clinical one can be arbitrary. We think that removing these descriptors and grouping articles by organ system (esophagus) or disease type (inflammatory bowel disease) will increase the chance that more readers will at least scan a broader array of articles reflecting areas of interest. Acknowledging that not all clinicians are molecular biology experts, nor do all laboratory scientists have in-depth clinical knowledge, future original research articles will feature call-out boxes that place the topic in context and point out, as appropriate, why a clinician should be aware of this basic/translational report or what questions a laboratory scientist might consider based on this clinical study. There are more than 15,000 biomedical journals published regularly. Staying current is a nearly impossible task. To try to lighten that load, we plan to change the current Selected Summaries section into the newly branded Gastro Digest. As before, this section will highlight recent publications in other journals of relevance to our readers. Coverage of articles will be reduced to bite-sized synopses, but the scope of journals reviewed will be broadened. Publications potentially outside a busy professional’s standard reading pool from topnotch journals like Nature, Cell, Science, New England Journal of Medicine, The Lancet, or Annals of Internal Medicine are only useful when readers are aware they exist. Other new or revised features planned for our tenure that will hopefully improve the accessibility of Gastroenterology material will include Gastro Grand Rounds, where a complex case will be discussed by a variety of disciplines; virtual journal clubs; and podcasts regarding key original research published in Gastroenterology. Each will exploit the possibilities offered by digital multimedia. Users will be able to access these materials when convenient from mobile devices. When possible, we will endeavor to make Continuing Medical Education credit available, recognizing the importance as well as the time demands of continuous learning. In summary, we have a tough editorial act to follow! Gastroenterology is and will continue to be an outstanding journal. The changes discussed above, and others to come, are intended to meet or exceed the expectations of readers, present and future, who come to Gastroenterology looking for a rewarding and entertaining way to stay abreast of important advances and ongoing controversies in our specialty. As Elena Verdu, MD, PhD, one of our Senior Associate Editors, described it—we want Gastroenterology to publish the first and the last word on topics of interest to our readers. Along with our new Board, that is a challenge we are ready to accept.